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Recent advances in myeloid-derived suppressor cell biology

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud

《医学前沿（英文）》 2021年 第15卷 第2期   页码 232-251 doi: 10.1007/s11684-020-0797-2

摘要： In recent years, studying the role of myeloid-derived suppressor cells (MDSCs) in many pathological inflammatory conditions has become a very active research area. Although the role of MDSCs in cancer is relatively well established, their role in non-cancerous pathological conditions remains in its infancy resulting in much confusion. Our objectives in this review are to address some recent advances in MDSC research in order to minimize such confusion and to provide an insight into their function in the context of other diseases. The following topics will be specifically focused upon: (1) definition and characterization of MDSCs; (2) whether all MDSC populations consist of immature cells; (3) technical issues in MDSC isolation, estimation and characterization; (4) the origin of MDSCs and their anatomical distribution in health and disease; (5) mediators of MDSC expansion and accumulation; (6) factors that determine the expansion of one MDSC population over the other; (7) the Yin and Yang roles of MDSCs. Moreover, the functions of MDSCs will be addressed throughout the text.

关键词： non-human primates (rhesus macaques)     myeloid-derived pro-inflammatory cells (MDPCs)     autoimmune disorders     alloimmune responses     pregnancy     mature MDSCs     multiple sclerosis     Yin-Yang law of MDSCs    

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SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES

《农业科学与工程前沿（英文）》 2021年 第8卷 第4期   页码 645-658 doi: 10.15302/J-FASE -2020350

摘要：

Superoxide dismutase (SOD) is an important enzyme in the antioxidant system of plants and plays a vital role in stress responses by maintaining the dynamic balance of reactive oxygen species (ROS) concentrations. Genome-wide analysis of the SOD gene family in various plant species has been conducted but little is known about this gene family in watermelon (Citrullus lanatus). Here, eight SOD genes were identified in the watermelon genome and are designated ClCSD1-5, ClFSD1-2 and ClMSD according to their metal cofactors. Phylogenetic analysis shows that SOD proteins from various plant species can be classified into five groups and members in the same group possess the same metal cofactor and similar subcellular localizations. Expression analysis of the ClSOD genes indicates that they had tissue-specific expression patterns with high expression in different tissues including the leaves, flowers and fruit. In addition, the expression of ClSOD genes differed appreciably under salinity, drought and abscisic acid (ABA) treatments, indicating that they may be involved in ROS scavenging under different abiotic stresses via an ABA-dependent signaling pathway. These results lay the foundation for elucidating the function of ClSOD genes in stress tolerance and fruit development in watermelon.

 

关键词： abiotic stress / expression analysis / phylogeny / SOD / superoxide dismutase / watermelon    

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Microbial responses to the use of NaClO in sediment treatment

《环境科学与工程前沿（英文）》 2022年 第16卷 第2期 doi: 10.1007/s11783-021-1451-1

摘要：

• Chlorine addition enhanced the release of TOC, TN from the sediment.

关键词： Sediment chlorination     Substance mobility     Microbial response     Community composition     Function    

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The critical role of autophagy in plant responses to abiotic stresses

Yu WANG,Jie ZHOU,Jingquan YU

《农业科学与工程前沿（英文）》 2017年 第4卷 第1期   页码 28-36 doi: 10.15302/J-FASE-2017130

摘要： Autophagy is an evolutionary conserved recycling process in eukaryotes whereby intracellular components are engulfed by autophagosomes, which are subsequently transferred to the vacuoles for further degradation and reuse. In organisms like yeast and metazoans, autophagy is actively engaged during environmental perturbation either by degrading denatured proteins and organelles or by interfacing with stress related signaling molecules. Studies over the last decade have also revealed numerous important mechanisms where autophagy is widely involved in plant abiotic stress responses. Autophagy serves as a pivotal route for nutrient remobilization by the degradation of superfluous or damaged cellular cytoplasmic material and organelles. It is also reported to regulate the accumulation of reactive oxygen species, to maintain the cellular redox balance of plants under stressful conditions. Furthermore, autophagy is essential in regulating cellular toxicity by removing aggregated and/or denatured proteins and thereby improving plant stress tolerance. In this review, recent advances in our understanding of autophagy, along with pathways and regulatory networks through which it influences many aspects of plant growth and development in response to nutrient starvation, oxidative stress, osmotic stress and extreme temperatures are discussed.

关键词： abiotic stresses     autophagy     extreme temperature     nutrient starvation     osmotic stress     oxidative stress    

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Integrated analysis of gut microbiome and host immune responses in COVID-19

《医学前沿（英文）》 2022年 第16卷 第2期   页码 263-275 doi: 10.1007/s11684-022-0921-6

摘要： Emerging evidence indicates that the gut microbiome contributes to the host immune response to infectious diseases. Here, to explore the role of the gut microbiome in the host immune responses in COVID-19, we conducted shotgun metagenomic sequencing and immune profiling of 14 severe/critical and 24 mild/moderate COVID-19 cases as well as 31 healthy control samples. We found that the diversity of the gut microbiome was reduced in severe/critical COVID-19 cases compared to mild/moderate ones. We identified the abundance of some gut microbes altered post-SARS-CoV-2 infection and related to disease severity, such as Enterococcus faecium, Coprococcus comes, Roseburia intestinalis, Akkermansia muciniphila, Bacteroides cellulosilyticus and Blautia obeum. We further analyzed the correlation between the abundance of gut microbes and host responses, and obtained a correlation map between clinical features of COVID-19 and 16 severity-related gut microbe, including Coprococcus comes that was positively correlated with CD3+/CD4+/CD8+ lymphocyte counts. In addition, an integrative analysis of gut microbiome and the transcriptome of peripheral blood mononuclear cells (PBMCs) showed that genes related to viral transcription and apoptosis were up-regulated in Coprococcus comes low samples. Moreover, a number of metabolic pathways in gut microbes were also found to be differentially enriched in severe/critical or mild/moderate COVID-19 cases, including the superpathways of polyamine biosynthesis II and sulfur oxidation that were suppressed in severe/critical COVID-19. Together, our study highlighted a potential regulatory role of severity related gut microbes in the immune response of host.

关键词： COVID-19     SARS-COV-2     gut microbiome     immune response    

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Analyses of the seismic responses of soil layers with deep deposits

LOU Menglin, LI Yuchun, LI Nansheng

《结构与土木工程前沿（英文）》 2007年 第1卷 第2期   页码 188-193 doi: 10.1007/s11709-007-0021-3

摘要： Several typical problems in the seismic response analysis of soil layers with deep deposits have been studied according to the seismic response analysis of the soil layer in the Shanghai region. The problems include the effect of the inclination of the bedrock under the soil layer on the seismic responses of the soil layer, the rationality of the artificial horizontal bedrock boundary in the soil layer, and the effect of the wave velocity of the bedrock and dynamic characteristics of the soil media on the seismic responses of the soil layer. Some results are obtained by numerical analysis. In the seismic response analysis, the effect of angle of inclination of the rock surface under the soil layer can be neglected if the angle is not more than two degrees. A significant error will be introduced in the calculation when the artificial horizontal rock surface is assumed in the soil layer according to the shear velocity of the soil media. The elasticity of the solid rock has little influence on the seismic response of the deep soil layer. The field investigation on the soil dynamic property should be paid more attention to.

关键词： little influence     layer     calculation     Shanghai     dynamic    

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BUILDING CLIMATE-RESILIENT FOOD SYSTEMS IN EAST AND SOUTHEAST ASIA: VULNERABILITIES, RESPONSES AND FINANCING

《农业科学与工程前沿（英文）》 2023年 第10卷 第1期   页码 16-30 doi: 10.15302/J-FASE-2023492

摘要：

● Food systems in East and Southeast Asia are vulnerable to global warming.

关键词： food systems     climate change     East     policy     resilience and Southeast Asia    

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SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES

Yong ZHOU, Linjuan OUYANG, Dahu ZHOU, Yicong CAI, Haohua HE

《农业科学与工程前沿（英文）》 2021年 第8卷 第4期   页码 645-658 doi: 10.15302/J-FASE-2020350

摘要： Superoxide dismutase (SOD) is an important enzyme in the antioxidant system of plants and plays a vital role in stress responses by maintaining the dynamic balance of reactive oxygen species (ROS) concentrations. Genome-wide analysis of the gene family in various plant species has been conducted but little is known about this gene family in watermelon ( ). Here, eight genes were identified in the watermelon genome and are designated , and according to their metal cofactors. Phylogenetic analysis shows that SOD proteins from various plant species can be classified into five groups and members in the same group possess the same metal cofactor and similar subcellular localizations. Expression analysis of the genes indicates that they had tissue-specific expression patterns with high expression in different tissues including the leaves, flowers and fruits. In addition, the expression of genes differed appreciably under salinity, drought and abscisic acid (ABA) treatments, indicating that they may be involved in ROS scavenging under different abiotic stresses via an ABA-dependent signaling pathway. These results lay the foundation for elucidating the function of genes in stress tolerance and fruit development in watermelon.

关键词： abiotic stress     expression analysis     phylogeny     SOD     superoxide dismutase     watermelon    

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Seismic responses of subway station with different distributions of soft soil in Tianjin

Dejian YANG,Meiling DUAN

《结构与土木工程前沿（英文）》 2014年 第8卷 第2期   页码 187-193 doi: 10.1007/s11709-014-0252-z

摘要： In connection with the practical project of Kunming Road station of Tianjin subway Line 3, the paper established a two-dimensional finite element model with visco-elastic boundary by using ANSYS and analyzed seismic responses of subway station with different distribution of soft soil. The nonlinear dynamic properties of soft soils are modeled by the KINH. And obtain the response rules about displacement and internal force on subway station in the general field soil and five different distributions of soft soil. Provide reference for improving the seismic performance of subway stations in Tianjin soft soil.

关键词： distribution of soft soil     soft soil in Tianjin     seismic response     ANSYS    

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Damage identification in connections of moment frames using time domain responses and an optimization

《结构与土木工程前沿（英文）》 2021年 第15卷 第4期   页码 851-866 doi: 10.1007/s11709-021-0739-3

摘要： Damage is defined as changes to the material and/or geometric properties of a structural system, comprising changes to the boundary conditions and system connectivity, adversely affecting the system’s performance. Inspecting the elements of structures, particularly critical components, is vital to evaluate the structural lifespan and safety. In this study, an optimization-based method for joint damage identification of moment frames using the time-domain responses is introduced. The beam-to-column connection in a metallic moment frame structure is modeled by a zero-length rotational spring at both ends of the beam element. For each connection, an end-fixity factor is specified, which changes between 0 and 1. Then, the problem of joint damage identification is converted to a standard optimization problem. An objective function is defined using the nodal point accelerations extracted from the damaged structure and an analytical model of the structure in which the nodal accelerations are obtained using the Newmark procedure. The optimization problem is solved by an improved differential evolution algorithm (IDEA) for identifying the location and severity of the damage. To assess the capability of the proposed method, two numerical examples via different damage scenarios are considered. Then, a comparison between the proposed method and the existing damage identification method is provided. The outcomes reveal the high efficiency of the proposed method for finding the severity and location of joint damage considering noise effects.

关键词： damage identification     beam-to-column connection     time-domain response     optimization    

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Electronic and mechanical responses of two-dimensional HfS

Mohammad SALAVATI

《结构与土木工程前沿（英文）》 2019年 第13卷 第2期   页码 486-494 doi: 10.1007/s11709-018-0491-5

摘要： During the last decade, numerous high-quality two-dimensional (2D) materials with semiconducting electronic character have been synthesized. Recent experimental study (Sci. Adv. 2017;3: e1700481) nevertheless confirmed that 2D ZrSe and HfSe are among the best candidates to replace the silicon in nanoelectronics owing to their moderate band-gap. We accordingly conducted first-principles calculations to explore the mechanical and electronic responses of not only ZrSe and HfSe , but also ZrS and HfS in their single-layer and free-standing form. We particularly studied the possibility of engineering of the electronic properties of these attractive 2D materials using the biaxial or uniaxial tensile loadings. The comprehensive insight provided concerning the intrinsic properties of HfS , HfSe , ZrS , and ZrSe can be useful for their future applications in nanodevices.

关键词： 2D materials     mechanical     electronic     DFT    

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Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

《农业科学与工程前沿（英文）》 2017年 第4卷 第3期   页码 260-267 doi: 10.15302/J-FASE-2016116

摘要： The innate immune response is the first line of defense against viral invasion and pro-inflammatory chemokines and cytokines have a critical function in the innate immune responses against virus infections. The ability of a rabies virus (RABV) to induce the expression of chemokines and cytokines can lead to viral clearance from the central nervous system (CNS), whereas the ability to evade such expression and activation contributes to virulence and pathogenicity. In this review, the crucial contribution of chemokines/cytokines to clearing RABV from the CNS is discussed, including recruiting leukocytes into the CNS, enhancement of blood brain barrier permeability and activation of various immune cells that are essential for viral clearance. In addition, recombinant RABV expressing cytokines and chemokines can induce elevated innate and adaptive immune responses which result in clearing an established wild-type RABV infection in the CNS.

关键词： antiviral     blood brain barrier     chemokines and cytokines     innate immunity     rabies virus    

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Chromium phytoextraction and physiological responses of the hyperaccumulator Swartz to plant growth-promoting

《环境科学与工程前沿（英文）》 2023年 第17卷 第1期 doi: 10.1007/s11783-023-1609-0

摘要：

● Improved Cr phytoextration efficiency was achieved by B. cereus inoculation.

关键词： Hexavalent chromium     Hyperaccumulator     Rhizobacteria     Leersia hexandra Swartz     Bacillus cereus     Consortia    

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Structural design and mechanical responses of closely spaced super-span double tunnels in strongly weathered

Jiaxin HE; Shaohui HE; Xiabing LIU; Jinlei ZHENG

《结构与土木工程前沿（英文）》 2022年 第16卷 第6期   页码 685-703 doi: 10.1007/s11709-022-0824-2

摘要： This paper presents a study of closely spaced double tunnels in Taizhou, China. One is Xiabei Mountain No. 2 four-line super-span high-speed railway tunnel (HRT), and the other is Xiabei Mountain double-line large-span subway tunnel (ST). The excavation spans of HRT and ST are 26.3 and 14 m, respectively. The two tunnels are located at different levels, and their separating distance is 17.2 m. Due to the short construction period, the HRT excavation was completed earlier than ST. The structural design of the HRT, taking account of the disturbance by the ST construction, was analyzed by a numerical simulation. It was found that the “yielding principle” design was more feasible than the “resistance principle” design when considering the safety and durability of the HRT secondary lining. The mechanical responses of the HRT during ST construction were comprehensively monitored and analyzed, including the vault settlement, horizontal convergence, surrounding rock pressure, and the internal stress in shotcrete and steel arch. Results show that the longitudinal influence range of the ST construction on the HRT was approximately 0.6–1.1 times the ST outer diameter; the disturbance was mainly generated in the ST upper bench excavation; and the final axial force of the HRT shotcrete was approximately 9–16 times that of the steel arch, which indicated that the shotcrete was the main bearing structure. The safety status of the HRT was assessed based on the monitoring data, and the minimum safety factors of the HRT shotcrete and steel arch were 1.61 and 1.89, respectively. Parametric studies were performed to show how the lining stress of HRT was affected by the relative angle, pillar width, ST excavation method and excavation footage. Finally, the design and construction optimization were proposed according to the monitoring data and parameter analysis results. This study might provide practical reference for similar projects.

关键词： double tunnels     super-span     structural design     mechanical response     numerical simulation     field monitoring    

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Neural networks modeling signal responses and taxol production of cultured Taxus chinensis cells induced

GONG Yanwen, REN Defeng, YUAN Yingjin

《化学科学与工程前沿（英文）》 2007年 第1卷 第2期   页码 118-122 doi: 10.1007/s11705-007-0022-8

摘要： Quantitatively describing the signal transduction process is important for understanding the mechanism of signal regulation in cells, and thus, poses both a challenge and an opportunity for chemical and biochemical engineers. An artificial neural network (ANN), in which we took the signal molecules as neural nodes, was constructed to simulate the generation of active oxygen species (AOS) in Taxus chinensis cells induced by a bio-elicitor. The relative contents of AOS in cells predicted by the ANN model agreed well with the experimental data and three notable stages of AOS increase were observed from the 3D figure of AOS generation. The robustness of AOS trajectories indicated that signal regulation in vivo was an integral feedback control model that ensured the adaptation of to environmental stress. The artificial neural network was able to predict taxol production as well as determine the optimal concentration of oligosaccharides needed for it.

关键词： transduction     chinensis     feedback     environmental     generation    

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标题 作者 时间 类型 操作

Recent advances in myeloid-derived suppressor cell biology

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud

期刊论文

SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES

期刊论文

Microbial responses to the use of NaClO in sediment treatment

期刊论文

The critical role of autophagy in plant responses to abiotic stresses

Yu WANG,Jie ZHOU,Jingquan YU

期刊论文

Integrated analysis of gut microbiome and host immune responses in COVID-19

期刊论文

Analyses of the seismic responses of soil layers with deep deposits

LOU Menglin, LI Yuchun, LI Nansheng

期刊论文

BUILDING CLIMATE-RESILIENT FOOD SYSTEMS IN EAST AND SOUTHEAST ASIA: VULNERABILITIES, RESPONSES AND FINANCING

期刊论文

SUPEROXIDE DISMUTASE FAMILY GENES IN WATERMELON AND THEIR RESPONSES TO DIFFERENT ABIOTIC STRESSES

Yong ZHOU, Linjuan OUYANG, Dahu ZHOU, Yicong CAI, Haohua HE

期刊论文

Seismic responses of subway station with different distributions of soft soil in Tianjin

Dejian YANG,Meiling DUAN

期刊论文

Damage identification in connections of moment frames using time domain responses and an optimization

期刊论文

Electronic and mechanical responses of two-dimensional HfS

Mohammad SALAVATI

期刊论文

Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection

Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU

期刊论文

Chromium phytoextraction and physiological responses of the hyperaccumulator Swartz to plant growth-promoting

期刊论文

Structural design and mechanical responses of closely spaced super-span double tunnels in strongly weathered

Jiaxin HE; Shaohui HE; Xiabing LIU; Jinlei ZHENG

期刊论文

Neural networks modeling signal responses and taxol production of cultured Taxus chinensis cells induced

GONG Yanwen, REN Defeng, YUAN Yingjin

期刊论文